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Resultados 120 resultados LastUpdate Última actualización 28/11/2022 [10:31:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days



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硼替佐米与青蒿琥酯的药物组合物、方法以及应用

NºPublicación: CN115381794A 25/11/2022

Solicitante:

东南大学

Resumen de: CN115381794A

本发明属于医药技术领域,公开了硼替佐米与青蒿琥酯的药物组合物、方法以及应用,乙醇注入法制备得到的青蒿琥酯‑硼替佐米脂质体,用于多发性骨髓瘤治疗。本发明进行细胞实验,在细胞水平验证青蒿琥酯‑硼替佐米脂质体对U266骨髓瘤细胞株的增殖抑制作用。实现青蒿琥酯‑硼替佐米脂质体有效的抗肿瘤作用,使用过程中安全、高效,为临床肿瘤化疗提供新的思路。

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一种融合纳米囊泡及其制备方法与应用

NºPublicación: CN115381880A 25/11/2022

Solicitante:

中山大学

Resumen de: CN115381880A

本发明涉及生物医学技术领域,具体公开了一种融合纳米囊泡及其制备方法与应用。本发明的融合纳米囊泡包括间充质干细胞囊泡和植物外泌体融合而成的膜结构。本发明首次将植物来源的外泌体与人来源的间充质干细胞囊泡进行膜融合制备融合纳米囊泡,本发明的融合纳米囊泡具有很好的靶向性和生物相容性,该融合纳米囊泡具有抗炎抗氧化作用,并且具有免疫调节功能,能有效治疗特异性皮炎和银屑病,为制备用于治疗自身免疫病特别是特异性皮炎和银屑病的药物提供了一种新来源。

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封装光敏剂的紫外交联桃胶多糖纳米球、制备方法及其应用

NºPublicación: CN115381947A 25/11/2022

Solicitante:

桂林理工大学南方科技大学

Resumen de: CN115381947A

本发明提供了一种封装光敏剂的紫外交联桃胶多糖纳米球、制备方法及其应用,该制备方法为:将1重量份的水解桃胶多糖、2‑5重量份的肉桂酸、0.1‑1重量份4‑二甲氨基吡啶、0.5‑5重量份的N,N‑二环己基碳二亚胺于氮气氛围下溶于无水的N,N‑二甲基甲酰胺中,在室温下反应24‑48小时后,加入冰乙醇沉淀、洗涤3次,于60度烘箱中干燥至恒重,得到两亲性桃胶多糖‑肉桂酸共聚物;将所述两亲性桃胶多糖‑肉桂酸共聚物溶于有机溶剂中,当完全溶解后缓慢滴入相当于有机溶剂体积4‑9倍的水,然后透析8‑24小时,即可得到封装光敏剂桃胶多糖‑肉桂酸纳米球;最后将得到的封装光敏剂桃胶多糖‑肉桂酸纳米球在紫外光下光照0.5‑2小时,得到封装光敏剂的紫外交联稳定的桃胶多糖纳米球。

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一种靶向肿瘤放疗增敏剂及其制备方法

NºPublicación: CN115381940A 25/11/2022

Solicitante:

武汉大学

Resumen de: CN115381940A

本发明公开了一种靶向肿瘤放疗增敏剂及其制备方法,属于肿瘤治疗领域。本发明的靶向肿瘤放疗增敏剂为装载锰羰基(MnCO)的外泌体纳米囊泡(MMV),其制备方法包括(1)培养肿瘤细胞;(2)提取肿瘤细胞的外泌体;(3)通过电转将MnCO转到外泌体中,得到装载MnCO的肿瘤来源外泌体纳米囊泡。本发明安全有效,为肿瘤治疗提供了新的方法或手段,并为肿瘤放射增敏治疗提供了一种简单可行的干预方法,具有良好的开发和应用前景。

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白蛋白负载阿苯达唑纳米药及其制备方法

NºPublicación: CN115381793A 25/11/2022

Solicitante:

吉林大学

Resumen de: CN115381793A

本发明提供了一种白蛋白负载阿苯达唑纳米药及其制备方法,属于生物纳米合成技术领域,其通过下述步骤得到:第一步将白蛋白、胰凝乳蛋白酶和弹性蛋白酶加入水中得到第一溶液;第二步,将阿苯达唑溶解于有机溶剂得到第二溶液,第三步将第一溶液与第二溶液充分混合;第四步和第五步进行去溶剂化交联,第六步先将第三步所得到的阿苯达唑纳米药进行透析纯化,第七步,将纯化后产物进一步加热固化然后冷却冻干获得纳米级阿苯达唑。本发明显著提高了阿苯达唑药物的溶解度和溶出速度,明显改善阿苯达唑生物利用度,有效地发挥阿苯达唑抗组织器官寄生虫的治疗作用。

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Coordination polymer nanometer material with photodynamic combined starvation treatment function as well as preparation method and application of coordination polymer nanometer material

NºPublicación: CN115381944A 25/11/2022

Solicitante:

中山大学附属第七医院(深圳)

CN_114452385_A

Resumen de: CN114452385A

The invention discloses a coordination polymer nano-material with a photodynamic combined hunger treatment function as well as a preparation method and application of the coordination polymer nano-material. The coordination polymer nano-material comprises a carrier and an enzyme, the enzyme is loaded in the carrier, and the enzyme is glucose oxidase or mimic enzyme with activity similar to that of the glucose oxidase; the carrier is a 1, 2, 4-triazole copper (I) complex. GOx in the coordination polymer nanometer material can be specifically released in tumor cells, glucose in the tumor cells can be catalyzed to be oxidized, glucose and oxygen in the tumor cells can be consumed, the acidity level, the hypoxia level and the hydrogen peroxide level are improved, and therefore energy supply of the tumor cells is blocked, and hunger treatment is achieved. Meanwhile, hydrogen peroxide generated in hunger treatment can be used as a raw material for photodynamic reaction of the 1, 2, 4-triazole copper (I) complex, the I-type photodynamic treatment effect is enhanced, and finally efficient photodynamic combined hunger treatment is achieved.

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RNA COMPOSITIONS TARGETING CLAUDIN-18.2

NºPublicación: CN115397856A 25/11/2022

Solicitante:

生物技术公司

AU_2021250814_PA

Resumen de: WO2021198157A1

The present disclosure provides RNA technologies for targeting Claudin-18.2 polypeptides. In some embodiments, such RNA technologies can be useful for treatment of diseases associated with positive expression of Claudin-18.2. For example, in some embodiments, such RNA technologies can be useful for treatment of Claudin-18.2 positive cancer, including, e.g, but not limited to biliary cancers, ovarian cancers, gastric cancers, gastro-esophageal cancers, pancreatic cancers. In some embodiments, such RNA technologies can be used in combination therapy (e.g, in combination with a chemotherapeutic agent).

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同时递送两亲活性物质的海藻酸钙微凝胶及其制备方法与应用

NºPublicación: CN115381770A 25/11/2022

Solicitante:

华南理工大学广东省体育科学研究所

Resumen de: CN115381770A

本发明属于医药技术领域,公开了一种同时递送两亲活性物质的海藻酸钙微凝胶及其制备方法与应用。本发明将疏水性的RES包裹进SNP制成R‑SNPs,提高RES溶解性与稳定性,进一步将R‑SNPs与亲水性的OPC共同裹入海藻酸钙微凝胶的方式实现两活性物质的靶向递送,不仅释药性好也可规避纳米粒子可能会产生的纳米毒性。所构建微凝胶为活性物质的靶向递送提供了一个新方向,为缓解溃疡性结肠炎开拓了新的前景。

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PRODUCTION AND FUNCTIONALIZATION OF NANOPARTICLES DERIVED FROM PHAGE T5 AND THERAPEUTIC USES

NºPublicación: JP2022549257A 24/11/2022

Solicitante:

サントルナショナルドゥラルシェルシュシアンティフィック

CN_114729375_A

Resumen de: WO2021053309A1

The present invention relates to phage T5 capsids that are devoid of genomic DNA from the phage and exposing, on their surface, at least one fusion protein of interest. The invention relates in particular to a phage T5 capsid that is deprived of genomic DNA from the phage and on its surface exposes at least one fusion protein, the fusion protein comprising: - at least one peptide fragment or protein fragment with at least 80% identity with a fragment of a decoration protein pb10; and - at least one functional fragment of an antigen, or at least one functional fragment of a toxin, or at least one receptor fragment, or at least one functional fragment of an addressing or targeting or transportation signal, or at least one functional fragment of an enzyme, or at least one functional fragment of a hormone, or at least one functional fragment of an antibody, or at least one antigen, or at least one toxin, or at least one receptor, or at least one addressing or targeting or transportation signal, or at least one enzyme, or at least one hormone, or at least one antibody, or any combination of these. The present invention also relates to methods for producing such a capsid and to vectors that enable the production thereof. The invention further relates to the fusion proteins of interest that are exposed on the capsid and to the nucleic acids encoding them. The invention also relates to nanoparticles comprising such functionalized capsids, pharmaceutical compositions comprising such n

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DMSO-FREE SYNTHESIS OF OLIGOPEPTIDE-MODIFIED POLY(BETA-AMINO ESTER)S AND THEIR USE IN NANOPARTICLE DELIVERY SYSTEMS

NºPublicación: JP2022549290A 24/11/2022

Solicitante:

イグザカフランス

CN_115175703_PA

Resumen de: WO2021053400A2

Methods for synthesizing and purifying oligopeptide-modified poly-beta-amino-esters (OM-PBAEs) and related polymers without using DMSO as a solvent yield OM-PBAEs with improved storage stability in biocompatible buffers. The polymers can be stored for extended periods and used to encapsulate nucleic acids and viral vectors losing transfection or transduction efficiency.

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BIO-MICROBUR THERAPEUTIC DELIVERY PLATFORM

NºPublicación: WO2022246285A1 24/11/2022

Solicitante:

THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK [US]

Resumen de: WO2022246285A1

The bio-microbur therapeutic delivery platform is a three-dimensional (3D)-oriented nanoneedle platform shaped like a microscale version of a fruit bur. The bio-microbur may be used for drug delivery and other biological applications, including without limitation delivery of oral vaccines or other oral biologics. Similar to a fruit bur's ability to adhere to different surfaces, the bio-microbur therapeutic delivery platform adheres to biological tissue, cell membranes, and biological gels. The bio-microbur therapeutic delivery platform includes a core and a plurality of nanoneedles secured to the core and extending outwardly therefrom, adapted for carrying and delivering a therapeutic agent. The treating agent may be an SSRI, such as fluoxetine.

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NUCLEIC ACID-CONJUGATED POLYMERIC NANOPARTICLES AND METHODS OF USE

NºPublicación: WO2022246093A1 24/11/2022

Solicitante:

THE BRIGHAM AND WOMENS HOSPITAL INC [US]
MASSACHUSETTS INSTITUTE OF TECH [US]

Resumen de: WO2022246093A1

A nanoparticle composition including: a first polymer conjugated to a drug by a linker to form a first polymer compound, the first polymer compound having a net negative charge; and a second polymer conjugated to at least one positively charged group to form a second polymer compound, the second polymer compound having a net positive charge, and the first polymer compound and the second polymer compound interacting electrostatically to form a nanoparticle.

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LIPID NANOPARTICLES

NºPublicación: WO2022244844A1 24/11/2022

Solicitante:

NATIONAL UNIV CORPORATION HOKKAIDO UNIV [JP]

Resumen de: WO2022244844A1

The present invention provides lipid nanoparticles that contain a pH-sensitive cationic lipid and a polyalkylene glycol-modified lipid. The pH-sensitive cationic lipid fraction of the total lipids that constitute the lipid nanoparticles is 10-25 mol%, the polyalkylene glycol-modified lipid fraction of the total lipids that constitute the lipid nanoparticles is 0.5-1.75 mol%, and the number average particle size of the lipid nanoparticles is at least 150 nm.

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ANTIBODY-CONJUGATED LIPOSOME

NºPublicación: WO2022242763A1 24/11/2022

Solicitante:

HIGHFIELD BIOPHARMACEUTICALS CORP [CN]

CN_115364237_A

Resumen de: WO2022242763A1

An antibody-conjugated liposome, particularly a nanoparticle. The surface of the nanoparticle contains antibodies. The number of the antibodies is 5-60, preferably 5-50, and more preferably 5-40. The nanoparticle, for example, a liposome, can more effectively exert a therapeutic effect on tumor and improve multidrug resistance of tumor, thereby overcoming the technical prejudice that it is commonly considered that the more antibodies on a surface of a liposome, the better the target cell binding effect, and laying a foundation for further clinical development.

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HIGH VOLUME FLOW-THROUGH ANTIGEN DETECTION SYSTEM

NºPublicación: WO2022246217A1 24/11/2022

Solicitante:

NORTHWESTERN UNIV [US]

Resumen de: WO2022246217A1

Methods, devices and kits for detecting an antigen in a sample using synthetic nanoparticles in flow (e.g., vertical flow or lateral flow) are provided.

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METHOD FOR PRODUCTION OF CELL-DERIVED NANOVESICLES BY USING HIGH-PRESSURE FLUID DISPERSION

NºPublicación: WO2022245144A1 24/11/2022

Solicitante:

NUMAIS CO LTD [KR]

Resumen de: WO2022245144A1

The present invention relates to: a method for production of cell-derived nanovesicles, the method comprising a step of lysing and dispersing cells under a high-pressure condition; and nanovesicles produced by the method. The method can produce cell-derived nanovesicles in uniform sizes and allows for mass production, compared to conventional methods, and thus can be advantageously used in the medical and pharmaceutical fields.

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MAGNETIC NANOPARTICLES FOR IMAGE DIAGNOSIS AND CONTRAST MEDIUM FOR IMAGE DIAGNOSIS

NºPublicación: WO2022244680A1 24/11/2022

Solicitante:

OSAKA UNIV [JP]

Resumen de: WO2022244680A1

The purpose of the present invention is to provide a contrast medium using a paramagnetic metal that accumulates at an abnormal protein deposition or aggregation site in the brain. Magnetic nanoparticles for image diagnosis which comprise magnetic iron oxide particles, gold fine particles supported on the surface of the magnetic iron oxide particles, a polymer chain attached to the gold fine particles and a molecule directing for a neurodegenerative disease-related protein and attached to at least a part of the polymer chain, and which are to be administered transnasally. These magnetic nanoparticles for image diagnosis are useful as an active ingredient of a contrast medium that accumulates at an abnormal protein deposition or aggregation site in the brain.

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THERMALLY STABLE LIPID-NUCLEIC ACID MOLECULE FORMULATIONS UTILISING METAL ORGANIC FRAMEWORK (MOF) SHELLS

NºPublicación: WO2022241513A1 24/11/2022

Solicitante:

COMMONWEALTH SCIENT AND INDUSTRIAL RESEARCH ORGANISATION [AU]

Resumen de: WO2022241513A1

The present application relates to metal-organic framework (MOF) encapsulation of lipid-nucleic acid formulations. The present application discloses methods for stabilizing lipid-nucleic acid formulations and provides MOF encapsulated lipid-nucleic acid formulations with improved stability.

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MAPPING NANOPARTICLES

NºPublicación: WO2022241506A1 24/11/2022

Solicitante:

FERRONOVA PTY LTD [AU]

Resumen de: WO2022241506A1

Nanoparticulate material suitable for administration to a subject, the nanoparticulate material having bound to its surface: (a) copolymeric steric stabiliser that promotes dispersion of the nanoparticulate material in a liquid, wherein the copolymeric steric stabiliser comprises (i) an anchoring polymer segment having one or more binding groups that bind the copolymeric steric stabiliser to the nanoparticulate material, and (ii) a steric stabilising polymer segment that is different from the anchoring polymer segment, and (b) copolymeric mapping moiety comprising (i) an anchoring polymer segment having one or more binding groups that bind the copolymeric mapping moiety to the nanoparticulate material, (ii) one or more mapping groups comprising an agent that specifically binds to fibroblast activation protein (FAP), and (iii) a coupling polymer segment that is different to the anchoring polymer segment, wherein the coupling polymer segment couples the anchoring polymer segment to the one or more mapping groups.

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POLYNUCLEOTIDES ENCODING METHYLMALONYL-COA MUTASE FOR THE TREATMENT OF METHYLMALONIC ACIDEMIA

NºPublicación: WO2022246020A1 24/11/2022

Solicitante:

MODERNATX INC [US]

Resumen de: WO2022246020A1

This disclosure relates to mRNA therapy for the treatment of methylmalonic acidemia (MMA). mRNAs for use in the invention, when administered in vivo, encode methylmalonyl-CoA mutase (MUT). mRNA therapies of the disclosure increase and/or restore deficient levels of MUT expression and/or activity in subjects.

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ANTI-OXIDANT CONTAINING PARTICLES AND METHODS OF USE

NºPublicación: WO2022246280A1 24/11/2022

Solicitante:

UNIV OF IOWA RESEARCH FOUNDATION [US]
GREINER MARK A [US]
SALEM ALIASGER K [US]
SCHMIDT GREGORY [US]
SKEIE JESSICA M [US]
SAHA SANJIB [US]
POLZ MEGAN [US]

Resumen de: WO2022246280A1

A composition comprising nanoparticles having a molecule that is a cell targeting or cell penetrating molecule and an anti-oxidant, and methods of making and using the composition, are provided.

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METHOD AND SYSTEM FOR THERMAL STIMULATION OF TARGETED NEURAL CIRCUITS FOR THE TREATMENT OF PARKINSON'S DISEASE

NºPublicación: US2022370816A1 24/11/2022

Solicitante:

KAMBIX INNOVATIONS LLC [US]

Resumen de: US2022370816A1

A method and system for noninvasively treating a neurodegenerative disorder, can involve determining characteristics indicative of physical attributes of a central nervous system, the characteristics including parameters for diminishing adverse impacts of a magnetothermal stimulation treatment for a neurodegenerative disorder with respect to the central nervous system, and applying as a part of the magnetothermal stimulation treatment and based on the characteristics of the physical attributes of the central nervous system, a magnetic field to the brain for a thermal stimulation of neuron cells within the brain.

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ANTIBODY-PROTAMINE FUSIONS AS TARGETING COMPOUNDS OF A PROTAMINE-BASED NANOPARTICLE

NºPublicación: WO2022243518A1 24/11/2022

Solicitante:

WESTFAELISCHE WILHELMS UNIV MUENSTER [DE]

Resumen de: WO2022243518A1

The present invention relates to a method of generating a nanoparticle comprising contacting (a) a fusion protein (A), said fusion protein (A) comprising an antibody (A1) and a positively charged polypeptide (A2); (b) a positively charged polypeptide (B); and (c) a negatively charged molecule (C); thereby forming a nanoparticle. The present invention also relates to a nanoparticle obtainable by a method of the invention, as well as to a nanoparticle comprising (a) a fusion protein (A), said fusion protein (A) comprising an antibody (A1) and a positively charged polypeptide (A2); (b) a positively charged polypeptide (B); and (c) one or more negatively charged molecule(s) (C). The present invention also relates to a composition comprising a nanoparticle of the invention and to a nanoparticle or composition of the invention for use in therapy.

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MYELOID CELL-TARGETED NANOPARTICLES AND RELATED COMPOSITIONS AND METHODS

NºPublicación: US2022370644A1 24/11/2022

Solicitante:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV [US]

WO_2021127000_A1

Resumen de: US2022370644A1

Provided are targeted nanoparticles. In certain embodiments, the targeted nanoparticles comprise a nanoparticle and a myeloid cell (MC) targeting moiety stably associated with the outer surface of the nanoparticle. According to some embodiments, the MC targeting moiety is an immunosuppressive myeloid cell (isMC) targeting moiety. In certain embodiments, the targeted nanoparticles further comprise a detectable label (e.g., an in vivo imaging agent), a drug, or both. Also provided are compositions comprising the targeted nanoparticles of the present disclosure. Methods of using the targeted nanoparticles to image MCs (e.g., isMCs) and/or to modulate and/or disrupt MCs (e.g., isMCs) are also provided.

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COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES WITH MODULAR FUNCTIONALITY

Nº publicación: US2022370635A1 24/11/2022

Solicitante:

SIXFOLD BIOSCIENCE LTD [GB]

US_2021330810_A1

Resumen de: US2022370635A1

The invention provides compositions containing cargo molecules attached to elements that improve the function of the cargo molecules in the body of a subject. The compositions are useful for therapeutic and diagnostic purposes. Furthermore, the invention outlines ways in which these compositions can be produced; the core molecule can be functionalized, via bioorthogonal click chemistry, in such a way as to impart modular characteristics. This functionalization simultaneously allows for loading of biologically relevant cargo and provides stabilization to the overall structure of the molecule.

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